Abstract: In our report, the mechanical pain threshold(MWT) of CCI pain models made with different thread materials and number of ligation rings were compared, and the easier methods of CCI(chronic constriction nerve injury model) were optimized and screened. Forty-two male SD rats were randomly divided into 7 groups, which were three CCI groups which is 4, 3 and 2 ring silk thread ligation, respectively, three CCI groups which is 4, 3 and 2 ring chromic gut thread ligation, respectively, and one group of sham-operation group(n=6); the left sciatic nerves in rats of 6 CCI groups were ligated with chromic gut and silk thread, respectively, the left sciatic nerves in rats of sham-operation group were exposed without ligation. After the model was established, the MWTs were determined. The results indicated that there are significant differences between two CCI groups of 4, 3 ring silk thread ligation, three CCI groups of 4, 3 and 2 ring chromic gut thread ligation, and one group of sham-operation group and their base threshold(P＜0.01); there are no significant differences between sham-operation group, base threshold of each group and CCI group of 2 ring silk thread ligation(P＞0.05); the MWTs before ligation surgery in CCI groups were different from their MWTs after surgery; the MWTs in CCI groups keep stable on 7, 14 and 21 days after surgery; there are no significant differences between the three chromic gut thread groups(P＞0.05). The three CCI groups of 4, 3 and 2 ring chromic gut thread ligation and two CCI groups of 4, 3 ring silk thread ligation produced stable neuralgia. According to MWT value and whether there were selfbites, the CCI group of 2 ring chromic gut thread ligation was the best model, which was the easiest operation and had low MWT value.